Gastric cancer
Conditions
Interventions
Opioid group (control group):Opioids for induction and maintenance of anesthesia
Esketamine group (experimental group):Esketamine for induction and maintenance of anesthesia
Sponsors
Jiangsu Provincial People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: (1) Patients undergoing elective laparoscopic radical gastrectomy; (2) Aged 18-75 years; (3) ASA grade II-III; (4) BMI: 18-30kg/m2; (5) Clearly understand and voluntarily participate in this study and sign the informed consent.
Exclusion criteria
Exclusion criteria: (1) Patients unable to provide informed consent and communication difficulties before surgery; (2) Allergic to any of the drugs in the study; (3) Risk of severe increases in intracranial pressure such as intracranial aneurysms, poorly controlled or untreated hypertension (SBP over 180mmHg at rest, DBP greater than 100mmHg), untreated or undertreated hyperthyroidism, combined ischemic heart disease, unstable angina or myocardial infarction within the past 6 months, combined congestive heart failure, combined with elevated intracranial pressure and central nervous system injury or disease, combined with high intraocular pressure (e.g., glaucoma), and penetrating ocular trauma, And eye surgery patients whose intraocular pressure should not be raised; (4) Severe liver dysfunction (Child-PughC grade), severe renal impairment (creatinine clearance < 30ml/min), or undergoing long-term dialysis; (5) Severe cardiovascular and cerebrovascular diseases (myocardial infarction, cardiac arrest, decompensated heart failure, arrhythmias such as second-degree or more atrioventricular block without pacemaker, congenital heart disease, severe valvular disease, massive cerebral hemorrhage or cerebral infarction, etc.) and respiratory diseases (history of asthma, COPD exacerbation, pulmonary resection, etc.); (6) Pregnant or lactating women; (7) Patients with severe consciousness disorder or mental system diseases (schizophrenia, mania, bipolar disorder, insanity, etc.) and cognitive dysfunction; History of chronic pain, preoperative use of psychotropic drugs/sedatives/painkillers/antidepressants; (8) Declined patients or other circumstances in which the investigator considers it inappropriate to participate in the trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Gastrointestinal gas discharge time; | — |
Secondary
| Measure | Time frame |
|---|---|
| VAS score;Assessment of the HAD scale;Dosage of vasoactive drugs during surgery; | — |
Countries
China
Contacts
Public ContactCHUN YANG
Jiangsu Provincial People's Hospital
Outcome results
None listed