pulmonary hypertension
Conditions
Interventions
Pulmonary arterial hypertension:None
Healthy control group:None
Pulmonary Hypertension Lung Transplant Patient Group:None
COPD Lung Transplant Patient Group:None
Sponsors
the First Affiliated Hospital of Guangzhou Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 81 Years
Inclusion criteria
Inclusion criteria: Patients 18 years of age and older; The diagnostic criteria for hemodynamics were: mean pulmonary artery pressure >20mm Hg (1 mmHg=0.133 kPa), pulmonary artery wedge pressure =15 mmHg, pulmonary vascular resistance >2 Wood units. Patients with Group 3 pulmonary hypertension should also meet: a one-second rate [FEV1/ forced vital capacity (FVC)] <70% as determined by pulmonary function examination; Chest CT confirmed diffuse parenchymatous lung disease. Chest CT confirmed bilateral bronchiectasis, including idiopathic bilateral involvement with bronchiectasis, sleep apnea syndrome, and pulmonary hypertension due to pulmonary dysplasia.
Exclusion criteria
Exclusion criteria: Patients with pulmonary arterial hypertension related to Pulmonary hypertension associated with left heart disease or Chronic thrombo-embolic pulmonary hypertension; as well as those with hematologic disorders, systemic diseases, metabolic disturbances, pulmonary tumor thrombotic microangiopathy, and fibrotic mediastinitis. Patients with concurrent tumors; hyperlipidemia, hepatitis B, diabetes or a family history of tumors or metabolic disorders are also not included. Acute respiratory infections and other significant organ infections should be considered separately.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Metabolomics of plasma;Plasma lipidomics;single-cell sequencing of blood;single-cell sequencing of Lung tissue; | — |
Countries
China
Contacts
Public ContactJian Wang
the First Affiliated Hospital of Guangzhou Medical University
Outcome results
None listed