Evaluation of the correlation between copper death inducers ferriredoxin 1, lipoic acid, and postoperative delirium incidence after heart valve replacement using propensity score matching method

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR2400088024

Enrollment

Unknown

Registered

2024-08-09

Start date

2024-08-10

Completion date

Unknown

Last updated

2024-08-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

postoperative delirium

Interventions

Observation group:None.

Eligibility

Sex/Gender

All

Age

18 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1.Age = 18 years old; 2. Plan to undergo visceral valve replacement surgery on a scheduled basis; 3. Sign an informed consent form.

Exclusion criteria

Exclusion criteria: 1. Preoperative communication methods (coma, deep dementia or speech impairment, severe visual and auditory impairment); 2. MMSE score is too low [blind<17 points, high school level<20 points, high school level (including technical secondary school)] <24 points]; 3. History of neurological or psychiatric disorders; 4. Diseases related to abnormal copper metabolism; 4. Abnormal coagulation function; 5. Severe liver, kidney or lung injury.

Design outcomes

Primary

Measure	Time frame
Cu2+concentration in serum; FDX1concentration in serum;Sulfuric acid concentration in serum;Postoperative delirium occurrence;CAM-ICU score;	—

Secondary

Measure	Time frame
Hemodynamic parameters;	—

Countries

China

Contacts

Public ContactGong Gu

the General Hospital of the Western Theater Command

gonggu68@163.com+86 173 6013 7572

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026