The impact of regional acidification technology on efficency of extracorporeal carbon dioxide removal combined continuous renal replacement therapy

Status

Active, not recruiting

Phases

Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2400087984

Enrollment

Unknown

Registered

2024-08-08

Start date

2024-09-02

Completion date

Unknown

Last updated

2024-08-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Respiratory critical illness

Interventions

Gourp A(non-acidification group):Implementing extracorporeal carbon dioxide removal through a renal replacement therapy platform.

Gourp B(acidification group):Implementing extracorporeal carbon dioxide removal through a renal replacement therapy platform, acidification blood by lactic acid infusion

Eligibility

Sex/Gender

All

Age

18 Years to 95 Years

Inclusion criteria

Inclusion criteria: 1.Acute Respiratory Distress Syndrome 2.Chronic Obstructive Pulmonary Disease 3.Severe asthma 4.Participant who refuse intubation but are willing to undergo extracorporeal carbon dioxide clearance therapy

Exclusion criteria

Exclusion criteria: 1. There are contraindications to anticoagulation 2. Irreversible multi organ dysfunction 3. Severe peripheral vascular lesions make it difficult to establish vascular access 4. Late stage pulmonary fibrosis

Design outcomes

Primary

Measure	Time frame
PaCO2;Pre-membrane carbon dioxide partial pressure ;Post-membrane carbon dioxide partial pressure ;	—

Secondary

Measure	Time frame
Duration of mechanical ventilat;	—

Countries

China

Contacts

Public ContactXu Zhihua

Mianyang Central Hospital

yokiku1@gamil.com+86 138 9019 9910

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026