Perioperative lung injury
Conditions
Interventions
Traditional lung protection group:Tidal volume set at 8 mL/kg PBW, PEEP at 8 cmH2O
Driving-pressure guided group:Adjust tidal volume between 4-8 mL/kg PBW to maintain driving pressure between 9±1 cmH2O, with PEEP set at 8 cmH2O.
Sponsors
China-Japan Friendship Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Patients undergoing elective lung wedge resection, lobectomy, or segmentectomy (with single-lung ventilation time > 1 hour). 2. Age = 18 years. 3. Signed informed consent form.
Exclusion criteria
Exclusion criteria: 1. ASA classification IV or higher. 2. NYHA functional class III or higher. 3. Severe respiratory diseases such as bullous emphysema, pneumothorax, COPD requiring oxygen therapy, and prior thoracic chemotherapy. 4. Pregnancy or lactation. 5. Enrollment in other studies. 6. Patient refusal to participate in this study. 7. BMI > 35 kg/m². 8. FEV1 less than 50% of predicted. 9. Coagulation disorders. 10. Use of immunosuppressive drugs within the three months preceding surgery.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Concentration of IL-6 in alveolar lavage fluid after OLV; | — |
Secondary
| Measure | Time frame |
|---|---|
| Concentration of IL-2, TNF-a, IL-8, IL-10 in alveolar lavage fluid after OLV ;Pulmonary complications 7 days postoperatively or pulmonary complications that occurred before discharge;Oxygenation index after OLV 45 minutes;Hospital time;Proportion of unplanned ICU admissions;Intraoperative complications;Extrapulmonary complications occurring within 7 days after surgery or before discharge; | — |
Countries
China
Contacts
Public ContactLi Weixia
China-Japan Friendship Hospital
Outcome results
None listed