diabetic kidney disease
Conditions
Interventions
intervention group:Henagliflozin Proline Tablets or in combination with metformin
control group:Sitagliptin phosphate or in combination with metformin
Sponsors
Guangdong Hospital of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: (1) Age =18 years and =75 years; (2) Meet the clinical diagnostic criteria for diabetes mellitus; (3) Meet the clinical diagnostic criteria for DKD stage 3; (4) Urine albumin creatinine ratio of 30mg/g-300mg/g on two out of three occasions and glomerular filtration rate =60 [ml/(min-1.73m2)]; (5) Signed informed consent.
Exclusion criteria
Exclusion criteria: (1) Persons who are pregnant or breastfeeding; (2) Persons with psychiatric illnesses who are unable to understand the nature, scope, and possible results of the study or who are unable to comply with medical advice; (3) Those with acute complications such as diabetic ketoacidosis, hyperglycemic hyperosmolar syndrome, and diabetic lactic acidosis; (4) Those with hematuria, obvious abnormal urinary tubular pattern, systemic or urinary tract infections, urinary stones, those with other renal diseases and renal vascular diseases in combination, severe cardiac and hepatic insufficiency, connective tissue disease, malignant tumors, stress, and those who have had a cardiac infarction, angina pectoris, or cerebral infarction within the last 6 months; (5) History of using nephrotoxic drugs within 1 month; (6) Sudden onset of edema with normal renal function. (7) Intractable hypertension.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| UACR;eGFR; | — |
Secondary
| Measure | Time frame |
|---|---|
| serum creatinine;urea nitrogen; | — |
Countries
China
Contacts
Public ContactFan Guanjie
Guangdong Hospital of Traditional Chinese Medicine
Outcome results
None listed