Postoperative pain
Conditions
Interventions
Ropivacaine group (group R):Local anesthetic liquid configuration: 40ml solution (containing 0.375% ropivacaine)
Dexamethasone as a ropivacaine adjuvant group ((group RS):Local anesthetic liquid configuration: 40ml solution (containing 0.375% ropivacaine + 10mg dexamethasone)
Dexmedetomidine as a ropivacaine adjuvant group ((group RM):Local anesthetic liquid configuration: 40ml solution (containing 0.375% ropivacaine + 1 µg/kg dexmedetomidine)
Mixture of dexamethasone and dexmedetomidine as a ropivacaine adjuvant group (group RSM):Local anesthetic liquid configuration: 40ml solution (containing 0.375% ropivacaine + 10mg dexamethasone + 1µg/
Sponsors
The Affiliated Hospital of Xuzhou Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: (1) Age 18-65 years old; (2) ASAI.-III. (3) elective unilateral VATS;
Exclusion criteria
Exclusion criteria: (1) Contraindications to regional nerve blocks, including skin infections or bleeding disorders at the site of the block; (2) Those who are allergic to any of the drugs used in this test and have contraindications; (3) Patients with severe cardiovascular and cerebrovascular diseases, respiratory diseases, diabetes mellitus and abnormal liver and kidney function before surgery; (4) History of chronic pain, long-term use of opioids, hormones or non-steroidal drugs; (5) Those who are unable to communicate normally: hearing impairment, language comprehension impairment, mental illness, etc.; (6) Bradycardia (< 50 beats/min); (7) BMI=30 kg/m^2; (8) Those who have participated in other investigators;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Effective analgesic duration; | — |
Secondary
| Measure | Time frame |
|---|---|
| NRS score;PCIA;Total opioid consumption of PCIA after surgery;Remedial analgesia;Postoperative recovery index;Ramsay rating;QoR-15 rating;Patient satisfaction;Intraoperative opioid dosage;Blood pressure, heart rate, SpO2 at different time points;The occurrence of intraoperative adverse reactions;Postoperative complications; | — |
Countries
China
Contacts
Public ContactLinlin Zhao
The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu Province
Outcome results
None listed