Effects of perioperative circadian rhythm changes on postoperative delirium in elderly patients undergoing lower limb orthopedic surgery: a prospective, observational, cohort study

Effects of perioperative circadian rhythm changes on postoperative delirium in elderly patients undergoing lower limb orthopedic surgery

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR2400087955

Enrollment

Unknown

Registered

2024-08-07

Start date

2024-08-11

Completion date

Unknown

Last updated

2024-08-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

postoperative delirium

Interventions

Lower extremity operation group of elderly patients:none

Eligibility

Sex/Gender

All

Age

60 Years to 100 Years

Inclusion criteria

Inclusion criteria: (1) Patients aged =60 years for elective surgery (2) ASA= level 3 (3) Lower extremity orthopedic surgery under elective general anesthesia

Exclusion criteria

Exclusion criteria: (1) Preoperative delirium (2) Preoperative chronic pain and neurological diseases (3) Taking sedative, antidepressant or anti-anxiety medication before surgery (4) Previous history of mental illness (5) There is a history of abuse of opioids, non-steroidal drugs, or other analgesic drugs (6) Left ventricular ejection fraction <40% cardiac insufficiency. (7) Severe renal insufficiency (EGFR<30ml/min/1.73m2). (8) Refusal to give informed consent

Design outcomes

Primary

Measure	Time frame
postoperative delirium;Morningness-Eveningness Questionnaire Self-Assessment (MEQ-SA) score;Pittsburg sleep quality index ;	—

Countries

CHINA

Contacts

Public ContactFeng Xiao

The Affiliated TCM Hospital of Southwest Medical University

2569613118@qq.com+86 180 0820 3915

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026