Role of methylation levels of the COMT, SCN9A, and OPRM1 genes in peripheral blood mononuclear cells in postoperative neuropathic pain

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR2400087952

Enrollment

Unknown

Registered

2024-08-07

Start date

2024-08-10

Completion date

Unknown

Last updated

2024-08-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

postoperative neuropathic pain

Interventions

acute postoperative pain group:None.

Postoperative subacute pain group:None.

postoperative neuropathic pain group:None.

normal group:None.

Eligibility

Sex/Gender

All

Age

40 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1: Selective thoracoscopic radical surgery for lung cancer; 2: American Society of Anesthesiologists (ASA) grade II or III; 3: Height: 155-185 cm and Weight: 45-85 kg.

Exclusion criteria

Exclusion criteria: 1: Preoperative left ventricular ejection fraction < 50 %; 2: Previous history of cardiac surgery; 3: Have a serious history of coronary heart disease, hypertension, diabetes and neurological and psychiatric diseases; 4: Severe lung or systemic diseases; 5: Dementia, Parkinson 's disease, stroke have been diagnosed; 6: Long-term use of psychotropic drugs; 7: Heart block and other serious arrhythmia; 8: hypothyroidism; 9: Severe hepatic and renal insufficiency; 10: Recent use of sedatives, analgesics or antidepressants.

Design outcomes

Primary

Measure	Time frame
The methylation levels of COMT gene, SCN9A gene and OPRM1 gene;	—

Countries

Chian

Contacts

Public ContactZhou Junhui

Henan Provincial Chest Hospital

zhoujunhui1985@126.com+86 158 0386 5536

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026