Rosacea
Conditions
Interventions
Group I:Compound heparin sodium Allantoin gel
Group II:HA emulsion
Sponsors
The Second Affiliated Hospital of Xi'an Jiaotong University
Eligibility
Sex/Gender
All
Age
18 Years to 50 Years
Inclusion criteria
Inclusion criteria: ? 18-60 year old patients with rosacea who meet the diagnostic criteria for rosacea in China 2021 with persistent erythema and papules/pustules ? Facial dermatoscopy shows characteristic changes in rosacea; ? No liver and kidney function abnormality, metabolic abnormality and Skeleton disease; ? No antibiotic treatment in the past 3 months; ? Sign an informed consent form and strictly adhere to the treatment plan.
Exclusion criteria
Exclusion criteria: ? Those who are currently pregnant or breastfeeding, or have a pregnancy plan within six months; ? Allergic to Hydroxychloroquine or Clindamycin hydrochloride or compound heparin sodium Allantoin gel Topical medication; ? Other serious systemic diseases such as malignant tumors and psychological disorders; ? Patients who cannot take Clindamycin hydrochloride and retinoic acid for other reasons; ? People who suffer from diseases due to repeated use of immune drugs or Corticosteroid or immune dysfunction. ? Patients who do not cooperate or have poor compliance.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinician’serythemaassessment,CEA;TransepidermalWaterLoss;Stratum Corneum Hydration; | — |
Secondary
| Measure | Time frame |
|---|---|
| Investigator’sglobalassessment,IGA;Rosacea Quality of Life Index(RQoL);Global Aesthetic Improvement Scale(GAIS);Patient’s self-assessment,PSA;Subject Satisfaction Scale(SSS); | — |
Countries
China
Contacts
Public ContactJiawen Wu
The Second Affiliated Hospital of Xi'an Jiaotong University
Outcome results
None listed