Interstitial cystitis
Conditions
Interventions
Experimental group:Bladder microbiota transplantation
Control group:Placebo
Sponsors
Wuxi No.2 People's Hospital
Eligibility
Sex/Gender
Female
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: Interstitial cystitis a)Age above 18 years old; b)Interstitial cystitis was diagnosed by clinical examination and diagnosis; c)Patients who failed to respond to conventional treatment or had recurrent attacks; d)Patients voluntarily participated in the treatment of bladder microbiota transplantation and signed the informed consent.; e)The patient had not received bladder microbiota transplantation; f)Be conscious and able to communicate in language normally. Bladder bacteria donors a)Healthy female, aged 18-30 years, with no bacterial or fungal infectious diseases of the bladder in the past 1 year, healthy work and rest, no bad living habits such as staying up late, and no use of antibiotics, probiotics or immunomodulators in the past 6 months; b)No history of drug and food allergy, no history of long-term medication; c)No underlying diseases, autoimmune diseases, parasitic infections and other disease states.
Exclusion criteria
Exclusion criteria: a)Suffering from severe cardiovascular and cerebrovascular diseases, respiratory system diseases, immune system diseases and severe liver and kidney damage; b)Suffering from severe mental illness, such as depression, generalized anxiety disorder, etc.; c)Patients with bladder tumor; d)Patients with allergic reactions to the treatment of bladder microbiota transplantation; e)Patients who fail to provide complete medical history or examination data; f)Unable to carry out this study due to various reasons, various tests are needed; g)Fever, pregnancy, lactation, severe systemic infection, etc. h)Use of antibiotics in the past 2 weeks; i)Use of probiotics or immunomodulators in the past 1 month.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Renal function;Urine analysis;16S rRNA sequence;Questionnaire;Urinary IgA;Amplification and quantitative culture of urine and feces were performed;Mass spectrum identification;Metagenome;Cystoscopy; | — |
Secondary
| Measure | Time frame |
|---|---|
| Glycosylated hemoglobin;Blood lgA;C-reactive protein;Liver function;Endotoxin;Infectious disease indicators; | — |
Countries
China
Contacts
Public ContactFeng Ninghan
Wuxi No.2 People's Hospital
Outcome results
None listed