Mild cognitive impairment
Conditions
Interventions
Real stimulation group:Real intermittent theta-burst stimulation combined with cognitive training
Sham stimulation group:Sham intermittent theta-burst stimulation combined with cognitive training
Sponsors
Foshan First People's Hospital
Eligibility
Sex/Gender
All
Age
53 Years to 74 Years
Inclusion criteria
Inclusion criteria: (1)50-75 years old. (2) Primary school education or above. (3) Right-handed. (4) Meeting the core clinical diagnostic criteria of MCI in Petersen RC(2004) : ? changes in cognitive function discovered and proposed by patients, informed persons, or physicians; ? Objective evidence of impairment in one or more cognitive domains, typically characterized by impairment in memory (1.5 standard deviations or more lower than the control level of memory decline for the same age and education); ? The complex instrumental daily ability may be slightly impaired, but the ability to maintain daily life and daily self-care is retained; ? There is not enough evidence of cognitive impairment to diagnose dementia; ? Exclude the cognitive dysfunction caused by vascular, traumatic or iatrogenic causes; ? Can provide evidence of a sustained decline in cognitive function over time. (5) Clinical Dementia Rating Scale (CDR) score = 0.5. (6) Skull magnetic resonance imaging (3.0T-MRI, General Electric Company, USA) to exclude a history of stroke and other neurological diseases (see exclusion criteria for details).
Exclusion criteria
Exclusion criteria: (1) Due to a history of stroke or other neurological diseases (such as leucoencephalopathy, brain trauma, brain tumors, inflammatory diseases of the central nervous system, epilepsy, etc.), systemic diseases (such as syphilis, hypothyroidism, severe anemia, depression, etc.), complicated with serious heart, liver, kidney, hematopoietic system diseases, lower extremity lesions (local muscle decline, lower extremity joint or vascular diseases), and Impairment of cognitive function or ability to walk daily due to previous surgical history. (2) Previous transcranial magnetic stimulation treatment. (3) There are communication disorders that affect cognitive function, such as vision, hearing and aphasia. (4) Unable to perform skull MR or TMS. (5) Alcohol, drug use, or severe sleep deprivation. (6) Individuals who have mental factors or refuse the experiment and do not cooperate with the completion of the experiment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cognitive scale assessment;n-back task test; | — |
Secondary
| Measure | Time frame |
|---|---|
| Neuroelectrophysiological examination;functional near-infrared spectroscopy evaluation; | — |
Countries
China
Contacts
Public ContactYukai Wang
Foshan First People's Hospital
Outcome results
None listed