chronic Low Back Pain
Conditions
Interventions
Capsaicin group:For subjects in the capsaicin group, 1 ml of Capzasin-HP cream (0.1% capsaicin, Averitas Pharma Inc.) was applied to two 5 cm × 10 cm areas in the paraspinal muscles of L2-L4. Then, th
Low back pain group:Without any intervention, fNIRS signals were directly collected. Retrospective pain VAS scores were performed before and after the collection.
Sponsors
Shanghai Changhai Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 30 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria for subjects with chronic low back pain (1) Meet the diagnostic criteria for chronic pain of the International Association for the Study of Pain (IASP), with a Visual Analogue Score (VAS) = 3 points; (2) Aged between 18 and 30 years old; (4) Clear consciousness, able to answer questions accurately, speak fluently, and have no hearing impairment; (5) Informed consent, agree to participate in this study and sign the informed consent form. 3. Inclusion criteria for healthy subjects (1) Aged between 18 and 30 years old; (2) No persistent pain in the past month. (3) No acute pain in the past week. (4) Sign the informed consent form.
Exclusion criteria
Exclusion criteria: (1) Patients with malignant tumors and serious heart, liver, kidney and other diseases; (2) Patients with skin damage at the site where capsaicin is applied; (3) Patients with a history of lumbar surgery, spinal fracture, pregnancy, rheumatic disease, cancer, pacemaker, severe deformity, and no congenital spinal abnormalities; (4) Patients who have previously met the diagnostic criteria for mental disorders in the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV); (5) Patients who have taken sedatives and hypnotic drugs within two weeks; (6) Patients who are allergic to capsaicin.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Differences in cortical blood flow responses and changes in brain functional connectivity between the two groups.; | — |
Secondary
| Measure | Time frame |
|---|---|
| Retrospective pain VAS score; | — |
Countries
China
Contacts
Public ContactFanfu Fang
Shanghai Changhai Hospital
Outcome results
None listed