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High-definition transcranial direct current stimulation combined trigeminal nerve electrical stimulation for disorder of consciousness: A randomized controlled study

High-definition transcranial direct current stimulation combined trigeminal nerve electrical stimulation for disorder of consciousness: A randomized controlled study

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2400087887
Enrollment
Unknown
Registered
2024-08-06
Start date
2024-09-01
Completion date
Unknown
Last updated
2024-08-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Disorder of consciousness

Interventions

conventional group:Conventional treatment, including drug therapy, passive motion, sensory stimulation, acupuncture and so on
TNS group:Trigeminal nerve electrical stimulation on the basis of conventional treatment
HD-tDCS group:High-definition transcranial direct current stimulation on the basis of conventional treatment
Combine group:High-definition transcranial direct current stimulation combined with trigeminal nerve electrical stimulation on the basis of conventional treatment

Sponsors

The Third Affiliated Hospital of Sun Yat-Sen University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 90 Years

Inclusion criteria

Inclusion criteria: This study included patients with disorder of consciousness from the Third Affiliated Hospital of Sun Yat-Sen University from September 2024 to December 2025. Inclusion criteria: 1. =18 years old; 2. Disorder of consciousness caused by trauma, stroke and hypoxia; 3. Duration =2 weeks; 4. Diagnosed as a vegetative state (VS/UWS) or MCS according to clinical diagnostic criteria and CRS-R; 5. Stable vital signs, no progressive neurological symptoms; 6. Voluntarily participate and sign the informed consent.

Exclusion criteria

Exclusion criteria: 1. History of brain tumors, traumatic brain injury, epilepsy (or electroencephalogram suggests epileptiform changes) or mental disorders; 2. Skull defect, intracranial hypertension, intracranial infection 3. Metallic or electronic device implants (such as pacemakers, cochlear implants, deep brain stimulators, aneurysm clips, internal fixation devices after ventriculoperitoneal SHTS, etc.) 4. Unstable heart disease, hypertension 5. Other serious diseases that may affect the study

Design outcomes

Primary

MeasureTime frame
CRS-R scale;—

Secondary

MeasureTime frame
electroencephalogram;fNIRS;—

Countries

China

Contacts

Public ContactHu Xiquan

Department of Rehabilitation Medicine, The Third Affiliated Hospital, Sun Yat-sen University

huxiquan@mail.sysu.edu.cn+86 189 2210 2910

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026