Post-spinal supine hypotension in parturients
Conditions
Interventions
Control group:Intravenous saline 2ml 10 min before anaesthesia in the control group
Experimental group:Intravenous ondansetron 4mg 10 min before anaesthesia in the experimental group
Sponsors
Hangzhou First People's Hospital
Eligibility
Sex/Gender
Female
Age
20 Years to 40 Years
Inclusion criteria
Inclusion criteria: 1: Full-term singleton pregnancies (>=37 weeks) with an ASA classification of II or less were scheduled for elective caesarean section under intrathecal anaesthesia. 2: aged 20-40 years. 3: able to provide voluntary informed consent.
Exclusion criteria
Exclusion criteria: 1: Contraindications to intrathecal anaesthesia; 2: age 40 years; 3: hypersensitivity to norepinephrine or ondansetron; 4: pre-existing hypertension or hypertension in the current pregnancy, cardio-vascular disease; 5: long QT interval syndrome; 6: multiple pregnancies; 7: diabetes mellitus; 8: body weight 80 kg and height 175 cm; 9: significant coexisting maternal disorders, abruptio placenta, placenta praevia.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| MEC90 of norepinephrine administered by intravenous pump for preventing post-spinal hypotension during cesarean delivery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Remedial dose of norepinephrine;Number of occurrences of hypertension;Number of occurrences of hypotension;Number of occurrences of bradycardia;Remedial dose of atropine;Neonatal Apgar score;Umbilical cord blood PH;Nausea and vomiting and other adverse reactions; | — |
Countries
China
Contacts
Public ContactJianliang Sun
Hangzhou First People's Hospital
Outcome results
None listed