hypertension
Conditions
Interventions
Control group (Part I):none
Part I experimental group(OSAS patient):none
Part II experimental group(OSAS group with cPAP treatment):Continuos Positive Airway Pressure
Part II experimental group(OSAS group without cPAP treatment):Continuous positive pressure ventilation was not performed
Sponsors
The Second Affiliated Hospital of Chongqing Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Age 18-75 years old 2. Patients with peripheral OSAS were diagnosed by sleep breathing monitoring 3. Can withstand carotid body function test 4. Ultrasonography can clearly identify the carotid body and measure the patient
Exclusion criteria
Exclusion criteria: 1. Patients with mixed or central OSAS 2. Patients identified by pulmonary function tests as having chronic obstructive pulmonary disease. 3. Patients with heart failure whose NYHA heart function rating is Grade III and above 4. Patients with medically difficult to control hypertension (systolic blood pressure =140mmHg or/and diastolic blood pressure =90mmHg) 5. Patients with pulmonary embolism or pulmonary hypertension 6. Patients who cannot tolerate or have contraindications for CB functional testing 7. Ultrasonography cannot detect patients with carotid bodies 8. Patients who do not want to participate in the program 9. Patients who are unable or unwilling to receive cPAP therapy (cPAP Intervention Trial)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| apnea-hypopnea index;Carotid body activity;inflammatory factor; | — |
Secondary
| Measure | Time frame |
|---|---|
| Carotid body volume;vascular endothelial function;heart rate variability; | — |
Countries
China
Contacts
Public ContactHuang Jing
The Second Affiliated Hospital of Chongqing Medical University
Outcome results
None listed