osteoarthritis of the knee
Conditions
Interventions
Group A:Patients received 200 mg celecoxib 2 hours before surgery as prophylactic pain control, and all were given 1 mL of a 100-mL mixture containing 2,000 mg of fentanyl on demand using an intraveno
200 mg of celecoxib, 37.5 mg of tramadol, and 650 mg of acetaminophen every 12 hours for six weeks postoperatively
Group B:From preoperative day 2 until the day before surgery, patients took celecoxib 200 mg twice daily (once after breakfast and once after dinner) for preoperative analgesia. After patients resumed
Sponsors
Honghui Hospital, Xi'an Jiaotong University
Eligibility
Sex/Gender
All
Age
50 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1) Diagnosed with osteoarthritis of the knee through clinical and imaging tests and scheduled to undergo initial total knee replacement; 2) Age = 50 years; 3) have no communication difficulties
Exclusion criteria
Exclusion criteria: 1) Previous open surgery on the same side of the knee; 2) having had an intra-articular knee injection or knee arthroscopy within the last three months; 3) is scheduled to have contralateral TKA surgery or any other surgical procedure during the study; 4) suffering from severe pre-operative comorbidities that could lead to hospitalisation during the study or illnesses that would seriously interfere with study participation; 5) Allergy to sulphonamides; 6) History of peptic ulcer disease or history of bleeding disorders; 7) Impaired hepatic function ((alanine aminotransferase (ALT) or menthionine aminotransferase (AST) >100 IU/L or elevated prothrombin time (International Normalised Ratio (INR)) >1.5), or known cirrhosis or liver transplantation; 8) Severe renal impairment (creatinine clearance less than 30 ml/min), previous renal transplantation or in renal dialysis; 9) History of alcohol or other drug abuse or dependence within 5 years prior to enrolment; 10) History of arrhythmia, heart failure, myocardial infarction or arrhythmia at the time of enrolment; 11) Previous history of uncontrolled hypertension with systolic blood pressure >180 mm Hg or diastolic blood pressure >110 mm Hg at enrolment; 12) Inability to complete the study questionnaire; 13) Refusal to sign the consent form; 14) Patients who refused to be randomised
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Morphine consumption; | — |
Secondary
| Measure | Time frame |
|---|---|
| Remedial analgesics;PCA consumption;VAS;brief pain inventory;Western Ontario and McMaster Universities;Knee range of motion;SF-36; | — |
Countries
China
Contacts
Public ContactXu Chao
Honghui Hospital, Xi'an Jiaotong University
Outcome results
None listed