Effect of liposomal bupivacaine on postoperative analgesia in patients undergoing craniotomy with scalp nerve block: a prospective, randomized, double-blind, controlled study

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2400087817

Enrollment

Unknown

Registered

2024-08-05

Start date

2024-09-01

Completion date

Unknown

Last updated

2024-08-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Craniotomy (brain tumors)

Interventions

Blank control group:0.9% saline 20ml Scalp nerve block(SNB)

0.5% ropivacaine group:0.5% ropivacaine 20ml SNB

1.3% bupivacaine liposome group:1.3% bupivacaine liposome 20ml SNB

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Patients scheduled for craniotomy, 2. Aged 18 years or over, 3. American Society of Anesthesiologists (ASA) grade I-III, 4. Body mass index (BMI) of 18-28kg/m².

Exclusion criteria

Exclusion criteria: 1. Emergency surgical patients, 2. Patients unable to understand or use NRS, MMSE, LANSS rating scales, 3. Allergy to anesthetics, 4. Glasgow Coma Scale score ?15, 5. History of opioid dependence, coagulation abnormalities, block site infection, pregnancy, and previous craniotomy.

Design outcomes

Primary

Measure	Time frame
NRS score at rest 0-72 hours after surgery;	—

Secondary

Measure	Time frame
Intraoperative opioid dosage;Intraoperative hemodynamic variables;Postoperative QoR-15 score;MMSE score;Postoperative NRS and LANSS scores;	—

Countries

China

Contacts

Public ContactJianning Lan

Department of Anesthesiology, Fujian Medical University Union Hospital

lanjning@fjmu.edu.cn+86 186 0694 0907

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026