shock
Conditions
Interventions
Exposure group (use Cipepofol for sedation):NA
Non-Exposure group (use sedatives other than cipepofol):NA
Sponsors
The Third People's Hospital of Chengdu
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1)Age = 18 years; 2)Receiving invasive mechanical ventilation with endotracheal intubation 1 hour within 6 hours before or after intubation.
Exclusion criteria
Exclusion criteria: 1)pregnant or breastfeeding patients, 2)with acute primary brain conditions (e.g., traumatic brain injury, intracranial hemorrhage, stroke, hypoxic brain injury); 3)confirmed or suspected spinal cord injury or other conditions causing permanent or long-term paralysis 4)known allergies to sedatives, analgesics, or vasopressors used in the study 5)receiving palliative care or expected to die within 48 hours; 6)those previously enrolled in this study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 28-day Vasopressor-Free Time; | — |
Secondary
| Measure | Time frame |
|---|---|
| total vasopressor dosage within the first 7 days post-enrollment;incidence of new organ failure;proportion of RASS measurements within the target sedation range within 7 days;28-day all-cause mortality;ICU-free days within 28 days;duration and incidence of delirium (delirium-free days at 28 days);ventilator-free days within 28 days; | — |
Countries
China
Contacts
Public ContactPeng-Lin Ma/Chuan Zhang
Guiqian International General Hospital/The Third People's Hospital of Chengdu
Outcome results
None listed