Diabetic nephropathy
Conditions
Interventions
Experimental group:Basic therapy combined with fecal bacteria transplantation (capsule)
Control group:Basic treatment combined with placebo capsules
Sponsors
The First Affiliated Hospital of the Air Force Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: a) Adult, age: 18-80 years old; b) Pathological diagnosis of diabetic nephropathy; c)eGFR>=30mL/min/ 1.73m^2; d) Have a fixed medication plan within the last 3 months; e) Urinary albumin/creatinine ratio 300 to 8000mg/g or 24-hour urinary protein 300 to 8000mg; f) Agree to participate in the project and sign the informed consent.
Exclusion criteria
Exclusion criteria: a) diabetic ketoacidosis, hyperosmolar non-ketotic coma, or acute complications of diabetes; b) The expected survival time of severe cardiovascular and cerebrovascular diseases, pulmonary insufficiency, malignant tumors and other diseases is less than 3 months; c) Aii autoimmune disease; d) gastrointestinal active bleeding; e) Acute gastroenteritis; f) have previously received or are receiving FMT treatment; g) HIV infection; h) Regular administration of probiotics within 3 months before enrollment i) mental illness or intellectual disability; j) Women who have a pregnancy plan or are breastfeeding within 18 months; k) Alcohol/drug abuse history; l) Other conditions deemed unsuitable for inclusion by the researchers.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Urinary albumin/creatinine ratio at 6 months compared with baseline; | — |
Secondary
| Measure | Time frame |
|---|---|
| Creatinine doubling, eGFR reduction >= 40%, or ESRD;Changes of fasting blood glucose at 6 and 12 months after enrollment;Changes of glycosylated hemoglobin at 6 and 12 months after enrollment;Changes of blood lipid concentration at 6 and 12 months after enrollment;Intestinal flora changed after 6 and 12 months;Adverse reactions during treatment and follow-up.; | — |
Countries
China
Contacts
Public ContactShiren Sun
The First Affiliated Hospital of the Air Force Medical University
Outcome results
None listed