perianal fistulizing Crohn's disease
Conditions
Interventions
Experimental group:Biologics combined with anal fistula closure clip
Sponsors
Nanjing University of Traditional Chinese Medicine Affiliated Hospital (Jiangsu Provincial Hospital of Traditional Chinese Medicine)
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Diagnosed as a pfCD patient who meets the above diagnostic criteria and has no severe infection in the anal fistula area. 2. Aged 18 to 65 years old, gender not limited. 3. Those who agree to participate in clinical research are willing to cooperate with clinical physicians to observe and sign informed consent forms.
Exclusion criteria
Exclusion criteria: 1. Pregnant or lactating women; 2. Individuals with severe infections in the rectum and anal canal; 3. Individuals with severe heart, liver, kidney diseases and coagulation dysfunction (including those undergoing anticoagulant therapy), a history of pelvic radiation therapy, severe immune dysfunction, and a recent (within 3 months) history of sclerosing agent injection therapy at the anal fistula site; 4. Individuals with mental abnormalities, cognitive and communication disorders, or high levels of mental stress that do not conform to the author's requirements; 5. Individuals with incomplete case information; 6. Medical staff determine that other users are not suitable;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical healing rate of fistula;Healing rate of fistula imaging;Clinical remission rate of CD;Endoscopic remission rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Fistula response rate;CD clinical response rate;Endoscopic response rate;The state of anal sphincter function; | — |
Countries
China
Contacts
Public ContactHao Wang
Nanjing University of Traditional Chinese Medicine Affiliated Hospital (Jiangsu Provincial Hospital of Traditional Chinese Medicine)
Outcome results
None listed