bronchopulmonary dysplasia
Conditions
Interventions
control group:None
low-dose group:Intratracheal infusion of MSCs 1 × 10 ^ 7/kg
high-dose group :Intratracheal infusion of MSCs 2 × 10 ^ 7/kg
Sponsors
Children's Hospital Affiliated to Zhejiang University School of Medicine
Eligibility
Sex/Gender
All
Age
No minimum to 1 Years
Inclusion criteria
Inclusion criteria: 1. gestational weeks 23-29, birth weight 500-1500g 2. no change or exacerbation after DART therapy and need positive pressure ventilation or FiO2>0.3 until 36 of corrected gestational weeks 3. severe BPD and used PS after birth 4. parents of the patients agree to participate in this clinical trial
Exclusion criteria
Exclusion criteria: 1. preterm, small for gestational age 2. maldevelopment deformity of trachea, bronchus and lung, inherited metabolic diseases 3. severe congenital heart disease 4. PVL 5. IVH over 3 class 6. severe sepsis 7. acute pneumorrhagia 8. Intracranial and extracranial diseases that affect respiratory rate and rhythm: Severe cranial diseases such as severe intracranial infections, intracranial tumors, severe brain injury after asphyxia, congenital central hypoventilation syndrome, etc. cause respiratory center dysfunction, while neuromuscular diseases such as Guillain-Barre Syndrome, congenital muscle weakness, diaphragmatic motor disorders, etc. cause respiratory muscle dysfunction; 9. Maternal use of hormones during pregnancy and congenital intrauterine infections.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| anaphylaxis;Infection situation;mortality;Tracheal intubation time; | — |
Secondary
| Measure | Time frame |
|---|---|
| Inflammatory factors;Oxygenation index;Respiratory system severity score; | — |
Countries
China
Contacts
Public ContactShu Qiang
Children's Hospital Affiliated to Zhejiang University School of Medicine
Outcome results
None listed