sepsis
Conditions
Interventions
Gold Standard:Clinical outcome
Index test:the serial expression of KDM5B on the CD4+ T lymphocytes
Sponsors
Shanghai East Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: 1. Age: >= 18 years; 2. A sepsis patient visiting the Shanghai East Hospital: in accordance with the definition of sepsis in "Sepsis 3.0", which is, sepsis is a life-threatening organ dysfunction caused by the imbalance of the host infection response 3. For patients with unknown organ dysfunction status or organ dysfunction before infection, the baseline SOFA score is set to 0, and the post-infection SOFA score >= 2 is used as the clinical diagnostic criteria for organ dysfunction. 4. Informed consent.
Exclusion criteria
Exclusion criteria: 1. Age: under 18 years; 2. Acute or chronic inflammatory diseases; 3. Presence of other conditions, such as tumors, renal diseases, autoimmune diseases, etc.; 4. Currently participating in or having participated in other clinical trials within the last month; 5. Alcohol or substance dependence in the past five years; 6. Suffering from mental illness and unable to obtain informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| KDM5B; | — |
Secondary
| Measure | Time frame |
|---|---|
| PCT;CRP;Lac;blood routine examination;inflammatory cytokines;coagulation function;AUC of ROC; | — |
Countries
China
Contacts
Public ContactTang Lunxian
Department of Internal Emergency Medicine and Critical Care, Shanghai East Hospital
Outcome results
None listed