Difficult-to-Wean
Conditions
Interventions
Conventional rehabilitation group:Within 24 hours of admission to RICU, all patients underwent functional assessment by a medical team consisting of clinicians, rehabilitation therapists and nurses, a
Early and precise rehabilitation group:Participants assigned to the treatment group were also thoroughly evaluated by a medical team of clinicians, rehabilitation therapists, and nurses, who were info
Sponsors
Beijing Rehabilitation Hospital of Capital Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 90 Years
Inclusion criteria
Inclusion criteria: ? Age =18 years old; ? Invasive mechanical ventilation (intubation or tracheotomy); ? Mechanical ventilation duration =96h, the preconditions for the machine to be withdrawn are met ?At least one failed attempt to withdraw the ventilator (re-need ventilator support within 48 hours after extubation) ? Willing to participate in the study and sign the informed consentsent;
Exclusion criteria
Exclusion criteria: ? Malignant arrhythmia or acute myocardial ischemia; ? pneumothorax, pulmonary bulla and barotrauma and other lung diseases; ? Hemorrhagic disease or abnormal coagulation mechanism with bleeding tendency; ? chest skin trauma; ? Pulmonary hypertension and pulmonary embolism; ? With a permanent or temporary pacemaker; ? There is malignant tumor; ?Present and previous history of neuromuscular diseases affecting respiratory muscle; ? Participated in another clinical study related to mechanical ventilation withdrawal; ? Can not cooperate with the study for any reason or the researcher thinks that it is not suitable to be included in this experiment;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Peak expiratory flow; | — |
Secondary
| Measure | Time frame |
|---|---|
| diaphragmatic excursion;Maximum inspiratory pressure;Diaphragm thickening rate;oxygenation index;respiratory rate;Mechanical ventilation duration;Length of ICU stay;Total hospitalization days;Cumulative incidence for death before successful weaning;Successful weaning and days on mechanical ventilation within 28 days prior to ICU admission;Cumulative incidence for successful weaningwithin 28 days prior to ICU admission;Hospitalization expenses;Place to go after discharge;MRC score;European Five-dimensional Scale score before discharge and three months after discharge; | — |
Countries
China
Contacts
Public ContactJiang Hongying
Department of Respiratory Rehabilitation Center, Beijing Rehabilitation Hospital of Capital Medical University
Outcome results
None listed