Parkinson's Disease Constipation
Conditions
Interventions
Sponsors
Shaoxing Hospital of Traditional Chinese Medicine,Shaoxing TCM Hospital Affiliated to Zhejiang Chinese Medical University
Eligibility
Sex/Gender
All
Age
35 Years to 80 Years
Inclusion criteria
Inclusion criteria: (1) Western medicine diagnosis consistent with both Parkinson's Disease (PD) and constipation criteria; (2) Traditional Chinese medicine diagnosis compatible with the criteria for tremor syndrome and constipation associated with the pattern of phlegm-heat stirring wind; (3) Patient age between 35 and 80 years; (4) Hoehn-Yahr staging from 1 to 4; (5) No use of laxatives within 2 weeks prior to treatment initiation, and capable of completing scheduled treatments and assessments as planned; (6) Clear mental state and stable vital signs; (7) Patient has provided informed consent and signed the informed consent form.
Exclusion criteria
Exclusion criteria: (1) Secondary Parkinsonian syndromes or Parkinson-plus syndromes of various types; (2) Patients with severe primary diseases of the circulatory system, digestive system, hematopoietic system, or malignant tumors, or those suffering from schizophrenia, mental retardation, or other severe psychiatric disorders that impair normal communication and cooperation in assessments and follow-ups; (3) Constipation caused by organic intestinal lesions such as incomplete mechanical bowel obstruction, megacolon, or suspected bowel obstruction, or constipation that cannot be solely explained by PD due to unknown reasons; (4) Patients with atopic constitution, a history of allergies to multiple Chinese herbs or their components, posing high risk for inclusion; (5) Poor compliance, refusal to take Chinese herbal granules, or inability to cooperate for other reasons; (6) Patients who have participated in other clinical trials within the past three months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Interleukin-6;Interleukin-8;Tumor Necrosis Factor Alpha;Cluster of Differentiation 3 positive;Cluster of Differentiation 4 positive;Cluster of Differentiation 8 positive; | — |
Countries
China
Contacts
Public ContactCHEN KEWEI
Department of Neurology Shaoxing Hospital of Traditional Chinese Medicine,Shaoxing TCM Hospital Affiliated to Zhejiang Chinese Medical University,Shaoxing,Zhejiang,China.
Outcome results
None listed