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Multimodal magnetic resonance imaging-based exploration of nociceptive pathway mechanisms in patients with adenomyosis with dysmenorrhea

Multimodal magnetic resonance imaging-based exploration of nociceptive pathway mechanisms in patients with adenomyosis with dysmenorrhea

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2400087746
Enrollment
Unknown
Registered
2024-08-02
Start date
2024-04-02
Completion date
Unknown
Last updated
2024-08-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Adenomyosis with dysmenorrhea

Interventions

Adenomyosis with dysmenorrhea group:N/A
Healthy group without pain:N/A

Sponsors

Guangdong Second People's Hospital
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
30 Years to 50 Years

Inclusion criteria

Inclusion criteria: (1) Diagnosed with adenomyosis through pelvic MR assessment; (2) Adenomyosis without fertility with gradual deterioration of dysmenorrhea, or combined with other symptoms such as menorrhagia and prolonged menstruation; (3) Dysmenorrhea lasted for at least 6 months; NRS score = 4 points; (4) Uterine embolization treatment is required and the complications that may be involved are understood; (5) Hormonal drugs or Mirena ring treatment is not effective or cannot be tolerated, refuses surgery, or has a history of multiple surgeries, and finds it difficult to undergo surgery again.

Exclusion criteria

Exclusion criteria: 1. Organic pelvic disease on MRI scan of the pelvis; 2. Use of oral contraceptives, hormonal supplements, herbal medications, or any centrally-acting medications (e.g., opioids and antiepileptic medications) within the last 3 months; 3. Any physical illnesses assessed on the basis of a clinical evaluation and medical records, such as brain tumors, hepatitis, or epilepsy; 4. Presence of other co-morbidities of chronic pain (e.g., tension-type headaches, fibromyalgia, back pain, etc.); 5. Contraindications to MRI examination ( e.g . Claustrophobia).

Design outcomes

Primary

MeasureTime frame
Brain structure and function images;

Secondary

MeasureTime frame
Hamiton Anxiety Scale;Hamiton Anxiety Scale;NRS;

Countries

China

Contacts

Public ContactWu Yunfan

Guangdong Second People's Hospital

wuyunfan2007@163.com+86 185 0748 6714

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026