Late-life depression
Conditions
Interventions
Percision therapy group:Identify subtypes by Semi-supervised learning, select individualized precision treatment plans based on these subtypes.
Conventional treatment group:Standard medication treatment plans based on clinical experience.
Sponsors
The Affiliated Brain Hospital of Guangzhou Medical University
Eligibility
Sex/Gender
All
Age
60 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Age = 60 years, regardless of gender; 2.Meeting the diagnostic criteria for Major Depressive Disorder according to DSM-5; 3.HAMD-17 score = 17; 4.Treatment-naive patients at first episode, or patients whose medication regimen has been stable for 4 weeks prior to enrollment, or patients who have relapsed and have not received antidepressant treatment for more than 6 months; 5.Agree to participate in the study and sign an informed consent form.
Exclusion criteria
Exclusion criteria: 1.Meeting the diagnostic criteria for other mental disorders as per DSM-5, such as bipolar disorder or schizophrenia; 2.High risk of suicide: HAMD-17 scale suicide item scores of 3 or 4, or assessed by the investigator as having a high risk of suicide; 3.Hypothyroidism or severe physical illnesses of the heart, liver, kidneys, etc., that contraindicate participation in the study; 4.Neurological conditions such as central nervous system infections, stroke, hydrocephalus, brain tumors, or epilepsy; 5.Currently participating in other clinical trials; 6.Contraindications for MRI examinations: presence of a pacemaker, history of brain surgery with retained aneurysm clips, etc.; 7.Any other condition assessed by the investigator as unsuitable for participation in the trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical remission rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Remission time;Response rate;Clinical Global Impression-Improvement;Clinical Global Impression-Severity;Hamilton Depression Scale;Hamilton Anxiety Scale;Cognitive test scores; | — |
Countries
China
Contacts
Public ContactNing Yuping
The Affiliated Brain Hospital of Guangzhou Medical University
Outcome results
None listed