non-alcoholic fatty liver disease
Conditions
Interventions
HIIT group:High-intensity intermittent exercise 3 times a week for 12 weeks
MICT group:Participate in moderate-intensity exercise three times a week for a period of 12 weeks.
Sponsors
Department of Endocrinology, Key Laboratory of Endocrinology, Ministry of Health, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences
Eligibility
Sex/Gender
All
Age
25 Years to 55 Years
Inclusion criteria
Inclusion criteria: 1. Moderate MAFLD with IHCL=10% was measured by MRS At age 18-55. 2. Meet the 2006 IDF diagnostic criteria for metabolic syndrome; 3. Cardiorespiratory endurance test: VO2max=20ml/min/kg and PHR/HRmax=80%.
Exclusion criteria
Exclusion criteria: 1. Weekly alcohol intake female >140g or male > 210g; 2. Viral hepatitis or other acute and chronic liver diseases (ALT=3ULN or TBIL=2ULN); 3. Unstable angina pectoris or uncontrolled arrhythmia or cardiac insufficiency (NYHA2 or higher); 4. valvular heart disease or cardiomyopathy, renal insufficiency (eGFR-EPI16.7mmol/L or <4mmol/L; 4) Severe diabetic complications; 7. Lipid-lowering, hypertensive and hypoglycemic drugs should be used stably for more than 3 months; 8. Chronic obstructive pulmonary disease and other movement contraindications.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| intrahepatocellular lipid (IHCL); | — |
Secondary
| Measure | Time frame |
|---|---|
| Body fat percentage;Muscle content;LDL-c;HDL-c;TG;FBG;HbA1c;ALT;AST; | — |
Countries
Chian
Contacts
Public ContactPing Fan
Peking Union Medical College Hospital
Outcome results
None listed