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Theta burst stimulation versus high-frequency repetitive transcranial magnetic stimulation in the treatment of upper limb movement disorders after stroke: a multicenter randomized, double-blind, controlled trial

Theta burst stimulation versus high-frequency repetitive transcranial magnetic stimulation in the treatment of upper limb movement disorders after stroke: a multicenter randomized, double-blind, controlled trial

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2400087675
Enrollment
Unknown
Registered
2024-08-01
Start date
2024-08-01
Completion date
Unknown
Last updated
2024-08-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

upper limb movement disorders after stroke

Interventions

iTBS group:iTBS mode was applied to M1 on the affected side, the stimulation intensity was 100%RMT, the stimulation time was 2s, the interval time was 8s, the total treatment time was 192s, 600 pulses
rTMS group:10Hz rTMS was applied to M1 on the affected side, the stimulation intensity was 100%RMT, the stimulation time was 2s, the intermittent time was 18s, the total treatment time was 1200s, 1200

Sponsors

Affiliated Hospital of North Sichuan Medical College
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 90 Years

Inclusion criteria

Inclusion criteria: (1) It met the diagnostic criteria of the Chinese Guidelines for the Diagnosis and Treatment of Acute Ischemic Stroke 2014 revised by the Branch of Neurology of the Chinese Medical Association and the Cerebrovascular Disease Group [10], and was confirmed by CT or MRI; (2) First onset, 1 month = stroke duration =6 months; (3) over 18 years of age; (4) Brunnstrom evaluation of the affected upper limb stage ? to ?; (5) The patient himself or his family members sign the relevant informed consent.

Exclusion criteria

Exclusion criteria: (1) Upper limb movement disorders caused by other neurological diseases, such as Parkinson's disease, Alzheimer's disease, motor neurone disease, craniocerebral trauma, cerebellar or brainstem stroke patients; (2) History of intractable epilepsy; (3) intracranial metal implants and/or cardiac metal implants; (4) pregnancy; (5) The vital signs are not stable, or in the acute stage of the disease; (6) Patients with poor cognitive function, abnormal mental behavior, etc., who cannot cooperate with relevant examination and treatment.

Design outcomes

Primary

MeasureTime frame
Fugl-Meyer Assessment Upper Limb;

Secondary

MeasureTime frame
modified Ashworth Scale;Modified Barthel Index;Wolf Motor Function Test;

Countries

China

Contacts

Public ContactYinxu Wang

Affiliated Hospital of North Sichuan Medical College

34089681@qq.com+86 134 3878 1951

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026