Cardiorenal Syndrome
Conditions
Interventions
Intervention group:Short Course Enhanced External Counterpulsation Combined with Loop Diuretics
Control group:Conventional therapy
Sponsors
The Third Affiliated Hospital of Sun Yat-sen University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1) Age = 18 years old; Gender unlimited; 2) Those who meet the diagnostic criteria for cardiorenal syndrome; 3) Determine the diagnosis of acute heart failure based on underlying cardiovascular disease, triggers, clinical manifestations (medical history, symptoms and signs), and various examinations (electrocardiogram, chest X-ray, echocardiography, NT proBNP = 300pg/ml); 4) Acute left heart failure complicated by acute AKI, with an increase of = 26.5µmol/L in blood creatinine within 48 hours, blood creatinine increases by = 1.5 times within 7 days or urine volume125pg/ml); 6) Diagnose chronic renal failure based on a history of basic kidney disease or nocturia, as well as various tests such as hemoglobin, blood calcium, blood phosphorus, iPTH, and renal ultrasound; 7) Voluntarily participate and sign an informed consent form. All answers above are "yes", and this subject can participate in the experiment.
Exclusion criteria
Exclusion criteria: 1) Pregnant and lactating women; 2) Patients who are unwilling or unable to cooperate with the study; 3) Patients with severe liver, brain, kidney, and mental illnesses; Patients with severe arrhythmia; Patients with aortic aneurysm or aortic dissection; Patients with significant hemodynamic disorders caused by heart valve disease and congenital heart disease; Patients with coagulation dysfunction; Malignant tumor patients; Patients with systolic blood pressure = 180 mmHg and/or diastolic blood pressure = 110 mmHg; Cardiogenic shock; Severe breathing difficulties accompanied by significant hypoxemia; Hemodynamic instability; End stage renal disease, anuria, urinary tract stenosis, stones, tumors, etc. which cause urinary disorders. 4) Patients who are considered unsuitable for inclusion due to other serious illnesses. If any of the above answers are "yes", this subject cannot participate in the experiment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Creatinine;The absolute changes of 24-hour intake and output; | — |
Secondary
| Measure | Time frame |
|---|---|
| Estimated glomerular filtration rate (eGFR);Blood urea nitrogen (BUN);Cystatin C;Urinary protein/creatinine ratio;Weight;N-terminal B-type natriuretic peptide precursor;Left ventricular ejection fraction;Maximal oxygen uptake;Endothelin-1;Vascular endothelial growth factor;Interleukin-10;Nitric oxide; | — |
Countries
China
Contacts
Public ContactZhaojun Xiong
The Third Affiliated Hospital of Sun Yat-sen University
Outcome results
None listed