Allogeneic kidney transplantation
Conditions
Interventions
Case series:None
Sponsors
The Second Hospital of Hebei Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Overall inclusion criteria: (1) Age 18-65 years old; (2) Receiving a kidney transplant for the first time; (3) The transplantation time exceeds 3 months; (4) The immunosuppression regimen for nearly 1 month was stable, and the renal function was stable. Exclusion criteria for intestinal flora indicators: (Changes in intestinal flora of patients are not observed in the following circumstances) (1) Acute/chronic rejection, infection, graft loss, gastrointestinal symptoms, etc., occurred during the study; (2) Concurrent use of related drugs that affect tacrolimus metabolism (except immunosuppressants) within 1 week; (3) Antibiotics, antifungal drugs and probiotics have been used within 4 weeks.
Exclusion criteria
Exclusion criteria: Exclusion criteria for intestinal flora indicators: (Changes in intestinal flora of patients are not observed in the following circumstances) (1) Acute/chronic rejection, infection, graft loss, gastrointestinal symptoms, etc., occurred during the study; (2) Concurrent use of related drugs that affect tacrolimus metabolism (except immunosuppressants) within 1 week; (3) Antibiotics, antifungal drugs and probiotics have been used within 4 weeks.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Human kidney survival rate;incidence of acute rejection;incidence of delayed recovery of transplant function;incidence of transplant kidney failure;incidence of recipient mortality; | — |
Secondary
| Measure | Time frame |
|---|---|
| Tacrolimus drug concentration;Blood routine examination;Blood biochemistry;Ultrasound examination of the transplanted kidney;Intestinal flora; | — |
Countries
China
Contacts
Public ContactLiu Kailong
The Second Hospital Of Hebe Medical University
Outcome results
None listed