Study on the EEG changes of different anesthetic drugs in response to binary sequences

Study on the EEG changes of anesthetic drugs with different mechanisms of action on binary sequences

Status

Recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2400087658

Enrollment

Unknown

Registered

2024-08-01

Start date

2024-08-09

Completion date

Unknown

Last updated

2025-08-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

none

Interventions

Trial 1:Thirty health study participants were recruited and given ratings while listening to 10 Recruit 30 health research participants, sit in front of a computer in a quiet room, and let the partici

Trial 2:Recruit 10 study participants, choose in a quiet room, wear a brain cap, put on headphones, participants sit in a quiet room, listen to the experiment in the first choice of 4 different diffic

Trial 2: Non-task group in the propofol group:Propofol group: 1. Use a TCI pump to inject propofol to achieve target effect site concentrations of 0, 1, 2, 3, and 4 mcg/mL. We maintained each target

Trial 2: Task-based control in the dexmedetomidine and propofol groups:Two drug interventions with different mechanisms of action (dexmedetomidine group/propofol group). After patients enter the room

Eligibility

Sex/Gender

All

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: Trial 1 Inclusion criteria: 1. Health study participants 2. Ages 18-60; Trial 2 Inclusion criteria: 1. ASA (American Society of Anesthesiologists' Classification of patients' physical state) I-II; 2. Ages 18-60; 3. BMI in the range of 18-25 kg/m^2; 4. Patients undergoing general anesthesia or brachial plexus block.

Exclusion criteria

Exclusion criteria: Trial 1 exclusion criteria: 1. Past history of psychological or neurological diseases; 2. Hearing impairment; Trial 2 exclusion criteria : 1. History of previous psychological or neurological disease; 2. History of severe head trauma; 3. Current use of psychotropic drugs; 4. Severe organ system dysfunction; 5. Patients with hearing impairment and possible airway difficulties.

Design outcomes

Primary

Measure	Time frame
64-lead EEG;	—

Secondary

Measure	Time frame
Depth of anesthesia monitoring (AI value);Observer’s assessment of alterness / sedation, OAA/S score;	—

Countries

China

Contacts

Public ContactWang yingwei; Xu Daojie

Huashan Hospital Affiliated to Fudan University

xudaojie@fudan.edu.cn+86 159 0178 7886

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026