Acute upper gastrointestinal bleeding
Conditions
Interventions
Experimental group:High-dose intravenous esomeprazole (centralized procurement)(8 mg/hour, 192 mg/day) was given with continuous instillation for = 2 days
Control Group:High-dose intravenous esomeprazole (Original drug) (8 mg/h, 192 mg/day) continued instillation for =2 days
Sponsors
Shenzhen People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: (1) Age 18 to 75; (2) Admission diagnosed with acute upper gastrointestinal bleeding (ICD-9); (3) After admission, receive high-dose intravenous PPI (8 mg/h, 192 mg/day) continuous instillation treatment, and the medication time is = 2 days.
Exclusion criteria
Exclusion criteria: (1) Patients with liver cancer; (2) Patients with severe immune system disorders who have recently taken glucocorticoids.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Further bleeding;Adverse reactions;high-dose PPI cost; | — |
Secondary
| Measure | Time frame |
|---|---|
| Death during hospitalization;Length of hospital stay;Secondary endoscopic treatment;Rehospitalization for bleeding within 30 days; | — |
Countries
China
Contacts
Public ContactXie Shou Xia
Shenzhen People's Hospital
Outcome results
None listed