Knee osteoarthritis
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: 1) aged between 60 and 80 years old; 2) a diagnosis of KOA in at least one knee, confirmed by the American College of Rheumatology's clinical criteria; 3) a Kellgren-Lawrence (K-L) radiographic grade of 2 or higher.
Exclusion criteria
Exclusion criteria: 1) presence of a neurodegenerative or neurosensory disorder affecting the knee, distinct from KOA; 2) a history of lower extremity joint trauma within the last three months; 3) a scheduled total knee replacement in the upcoming months; 4) a documented allergy to traditional Chinese herbs; 5) prior treatment for KOA with steroids, intra-articular injections, or other analgesics within the past three months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Visual analogue scale (VAS) ;The Western Ontario and McMasters University Osteoarthritis Index (WOMAC); | — |
Secondary
| Measure | Time frame |
|---|---|
| Hip and knee muscle strength;Range of motion of hip and knee;Alignment;Joint space;Tumor necrosis factor-a (TNF-a);Interleukin-1ß (IL-1ß);interleukin-15 (IL-15);C1q/tumour necrosis factor-related protein-9 (CTRP9);interleukin-29 (IL-29);interleukin-34 (IL-34);interleukin-37 (IL-37);interleukin-6 (IL-6); | — |
Countries
China
Contacts
Kunming Second People's Hospital