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Clinical study and mechanism exploration of self-made Sanqi external application combined with pulse magnetic therapy for the treatment of knee osteoarthritis

Clinical study and mechanism exploration of self-made Sanqi external application combined with pulse magnetic therapy for the treatment of knee osteoarthritis - External application of traditional Chinese herb and knee osteoarthritis

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2400087644
Enrollment
Unknown
Registered
2024-07-31
Start date
2024-08-05
Completion date
Unknown
Last updated
2024-08-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Knee osteoarthritis

Interventions

External application of traditional Chinese herbs group:The compound prescription of traditional Chinese herbs was developed in accordance with the principles of the "Inner Canon of the Yellow Emperor
Pulse magnetic therapy group:Participants were positioned either supine or in a long-sitting position on the treatment bed for PEMF therapy. The magnetic field was induced using two pairs of solenoid
Combined treatment group:These two treatments are conducted simultaneously.
control group:All participants across the four gr

Sponsors

Kunming Second People's Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
60 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1) aged between 60 and 80 years old; 2) a diagnosis of KOA in at least one knee, confirmed by the American College of Rheumatology's clinical criteria; 3) a Kellgren-Lawrence (K-L) radiographic grade of 2 or higher.

Exclusion criteria

Exclusion criteria: 1) presence of a neurodegenerative or neurosensory disorder affecting the knee, distinct from KOA; 2) a history of lower extremity joint trauma within the last three months; 3) a scheduled total knee replacement in the upcoming months; 4) a documented allergy to traditional Chinese herbs; 5) prior treatment for KOA with steroids, intra-articular injections, or other analgesics within the past three months.

Design outcomes

Primary

MeasureTime frame
Visual analogue scale (VAS) ;The Western Ontario and McMasters University Osteoarthritis Index (WOMAC);

Secondary

MeasureTime frame
Hip and knee muscle strength;Range of motion of hip and knee;Alignment;Joint space;Tumor necrosis factor-a (TNF-a);Interleukin-1ß (IL-1ß);interleukin-15 (IL-15);C1q/tumour necrosis factor-related protein-9 (CTRP9);interleukin-29 (IL-29);interleukin-34 (IL-34);interleukin-37 (IL-37);interleukin-6 (IL-6);

Countries

China

Contacts

Public ContactYang Lei

Kunming Second People's Hospital

leon_yang30@163.com+86 150 2515 3703

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026