Postoperative delirium
Conditions
Interventions
Dexmetomidine group:The loading dose was given slowly intravenously at 0.5 ug/kg before induction of anesthesia and then continuously pumped at 0.4 ug/kg/h until 1 hour before the end of surgery
Control group:The same volume of saline was given before and during anesthesia induction
Sponsors
The First Affiliated Hospital of Zhengzhou University
Eligibility
Sex/Gender
All
Age
65 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. Age 65 or older than 85; 2. Asa Class III-IV;. 3.Planning major abdominal surgery 4. The estimated operative time was > 2 hours; 5. The participants agreed to participate in the study and signed the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Refusal to participate in the study, 2. emergency surgery, 3. preoperative delirium, 4. previous schizophrenia, epilepsy, Parkinson, myasthenia gravis, 5. continuous benzodiazepine use for more than a week, 6. severe liver damage (child-Pugh class C) , severe renal damage (requiring renal replacement therapy) 7. severe preoperative coma, dementia, or inability to communicate
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of delirium was 3 days after operation; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of delirium in awakening period;Classification of delirium;The levels of IL-6 and il-1ß were measured by Elisa before and after operation; | — |
Countries
China
Contacts
Public ContactLi Da
The First Affiliated Hospital of Zhengzhou University
Outcome results
None listed