Pain, restlessness
Conditions
Interventions
Group FP:Fospropofol Disodium 3.5mg/kg/h continuous intravenous pump
Group P:Propofol 1.0~4.0 mg/kg/h continuous intravenous pump
Group M:Midazolam 0.02~0.1mg/kg/h continuous intravenous pump.
Sponsors
Lanzhou University Second Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: ? Aged =18 years and =80 years old, regardless of gender; ? Patients who need analgesia and sedation when admitted to ICU; ? Mechanical ventilation is expected to be performed for > 24 hours; ? Obtain informed consent from patients or family members.
Exclusion criteria
Exclusion criteria: ? Pregnant or lactating women; ? Allergy to trial drugs or contraindications to the use of opioids; ? Patients with severe craniocerebral injury, brain tumors, increased intracranial pressure, etc. who are prone to respiratory depression; ? Severe, existing substantial liver disease With clinically significant portal hypertension, Child-Pugh class C cirrhosis or acute liver failure; ? Intestinal obstruction at risk (those who have or are at risk of progressing to gastrointestinal obstruction, especially patients with paralytic ileus); ? Hearing or Loss of vision, or any other condition that may seriously interfere with the collection of research data; ? Patients with mental or neurological diseases, cognitive and consciousness disorders, and unable to express correctly; ? Have participated in this research or participated in any other research at the same time; ? Unable to obtain informed consent or authorization.
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Delirium incidence;nausea and vomiting incidence; | — |
Primary
| Measure | Time frame |
|---|---|
| Time to achieve sedation goal;Mechanical ventilation time, extubation time, ICU stay time; | — |
Countries
China
Contacts
Public ContactFang Feng
Lanzhou University Second Hospital
Outcome results
None listed