None listed
Conditions
Interventions
Saline Group:Normal saline
Esketamine Group:0.5mg/kg esketamine
Sponsors
Guangzhou Women and Children’s Medical Center
Eligibility
Sex/Gender
All
Age
3 Years to 6 Years
Inclusion criteria
Inclusion criteria: 1) Age between 3-6y, gender is not limited; 2) Laparoscopic day surgery is planned to be performed under general anesthesia using a laryngeal mask airway; 3) ASA anesthesia grade I to II; 4) The parents or legal guardians of the affected child have signed an informed consent form for medical research.
Exclusion criteria
Exclusion criteria: 1) Children with allergies to ketamine and its components; Children with severe thrombocytopenia and gastrointestinal ulcers. 2) Analgesics, sedatives, antiemetics, and antipruritic drugs were used 24 hours before surgery; 3) Children with symptoms of acute upper respiratory tract infection before surgery; 4) Children with a history of bronchial asthma; 5) Children with severe sleep apnea syndrome and arrhythmia; 6) Has a history of abnormal surgical anesthesia recovery in the past; Preoperative assessment of the presence or possibility of difficult airway conditions 7) Renal dysfunction (BUN and/or Cr>upper limit of normal value); Liver function damage (ALT and/or AST>1.5 times the upper limit of normal values); 8) Children who are deemed unsuitable for inclusion by researchers due to other circumstances.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| LMA removal time; | — |
Secondary
| Measure | Time frame |
|---|---|
| the length of PACU stay;BIS value; | — |
Countries
China
Contacts
Public ContactNa Zhang
Guangzhou Women and Children's Medical Centre
Outcome results
None listed