None listed
Conditions
Interventions
normal saline group:Sufentanil 0.1µg/kg, saline equivalent to lidocaine, propofol 1.0mg/kg were administered in sequence, followed by additional propofol as needed during the examination
lidocaine group:Sufentanil was administered 0.1µg/kg, lidocaine 1.5mg/kg, and propofol 1.0mg/kg, followed by additional propofol as needed during the examination.
Sponsors
The First Affiliated Hospital of Soochow University
Eligibility
Sex/Gender
All
Age
65 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Patients aged 65 to 80 years; 2. ASA physical status I to III; 3. BMI 18-30 kg/m^2; 4. Scheduled for same-visit bidirectional endoscopy under sedation.
Exclusion criteria
Exclusion criteria: 1. Patients with endoscopic operation contraindications or refusal of anesthesia. 2. Uncontrolled circulatory and respiratory diseases that may threaten life, such as acute coronary syndrome, uncontrolled severe hypertension (systolic blood pressure =180mmHg, diastolic blood pressure =110mmHg), severe arrhythmia, heart failure, acute respiratory infection, asthma attack, active massive hemoptysis, Liver dysfunction (Child-Pugh grade C or above), acute upper gastrointestinal bleeding with shock, severe anemia (Hb<6g/dl), gastrointestinal obstruction with gastric content retention. 3. Without an escort or guardian. 4. Have sedation or anesthesia drug allergy or patients with severe allergic history and family history.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| a composite outcome of desaturation and hypotension; | — |
Secondary
| Measure | Time frame |
|---|---|
| total dose of propofol;pain scores;fatigue scores;Body movement response;recovery time; | — |
Countries
China
Contacts
Public ContactFuhai Ji
The First Affiliated Hospital of Soochow University
Outcome results
None listed