Acute gastrointestinal injury in the early stage after cardiopulmonary bypass
Conditions
Interventions
Experimental group :Fecal microbiota transplantation
Control group:Compound lactic acid bacteria capsule
Sponsors
The First Hospital of Lanzhou University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1.Patients who develop acute gastrointestinal injury within one week after undergoing cardiopulmonary bypass heart surgery, and are diagnosed with AGI levels II-IV. 2.Patients age range is from 18 to 70. 3.Study participants and their families should be informed about the study and sign consent forms.
Exclusion criteria
Exclusion criteria: 1. Patients with perioperative gastrointestinal hemorrhage; 2..Patients who are using strong antibiotics such as third-generation cephalosporins or carbapenems alone, or any combination of two or more antibiotics; 3. Patients with a history of chronic gastrointestinal disease or gastrointestinal surgery; 4. Patients were diagnosed with systemic diseases before surgery, such as malignant tumor, metabolic syndrome, connective tissue disease, congenital or acquired immune deficiency disease, etc. 5.Patients had severe organ dysfunction before surgery, such as heart, lung, liver, and kidney failure, etc; 6. Patients has a history of chemotherapy and radiation therapy; 7. Pregnant and lactating women; 8. The subjects and their families did not sign the informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of improved gastrointestinal function in patients one week after intervention;AGI Diagnosis Classification; | — |
Secondary
| Measure | Time frame |
|---|---|
| 16S rRNA sequencing results of intestinal flora of patients before and after intervention;Intestinal flora metabolites of patients before and after FMT intervention;DAO;D-Lactate;IL-6;IL-1ß;Immunoglobulin;T-cell subsets;Sequential Organ Failure Assessment;Length of Stay;Duration of Mechanical Ventilation;Duration of Mechanical Ventilation;Incidence of Adverse Events;Mortality rate;CRP; | — |
Countries
China
Contacts
Public ContactWenjun Zhou/ Jian Liu
The First Clinical Medical College of Lanzhou University;Gansu Provincial Maternity and Child Health Hospital/Gansu Provincial General Hospital,
Outcome results
None listed