Cardiovascular health
Conditions
Interventions
the experimental group (exercise, ACE II, ID, DD genotypes) :Experimental group participants engage in water-based exercise three times a week for 12 weeks.
the control group (no exercise):Control group participants do not engage in water-based exercise during the experiment and continue their normal activities.
Sponsors
Nanjing Normal University
Eligibility
Sex/Gender
Female
Age
45 Years to 75 Years
Inclusion criteria
Inclusion criteria: According to previous studies, the proportion of individuals with the ACE DD genotype is approximately 11%. Therefore, in the first phase of this study, we plan to recruit 100-200 postmenopausal women aged 45-75 from the Nanjing area for ACE testing. This is to ensure an adequate sample size of ACE II, ID, and DD genotypes for the second phase exercise trials. At least 20 participants with the ACE DD genotype and 20 participants without the ACE DD genotype (II and ID genotypes), as well as 40 control group participants, will actually take part in the second phase exercise trials. The subjects will primarily be individuals without skeletal, joint, or cognitive diseases, and without uncontrolled hypertension or metabolic diseases.
Exclusion criteria
Exclusion criteria: Recent use of ACE inhibitor medications, hospitalization within the past three months, cardiovascular diseases, uncontrolled hypertension and metabolic disorders, neuromuscular or respiratory diseases, skin diseases, mobility impairments, fear of water, and cognitive disorders.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Angiotensin converting enzyme; blood glucose;blood lipid;cholesterol;brachial-ankle pulse wave velocity;carotid intima-media thickness;dynamic balance;Flexibility of upper and lower limbs; | — |
Secondary
| Measure | Time frame |
|---|---|
| ankle-brachial index;heart rate;grip strength;Muscle endurance of lower limbs;agility; | — |
Countries
China
Contacts
Public ContactYan Nan Zhao
Nanjing Normal University
Outcome results
None listed