diabetes gastrointestinal motility disorder
Conditions
Interventions
Washed Microbiota Transplantation group:Washed Microbiota Transplantation
Sponsors
The Second Affiliated Hospital of Nanjing Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Diagnosed with type 1 or type 2 diabetic gastrointestinal motility disorders (including diabetic gastroparesis, diabetic diarrhea, diabetic constipation, etc.); 2. Age between 18 and 75 years old; 3. Glycosylated hemoglobin (HbA1c) <11%; 4. Inadequate response to conventional treatments for at least twelve weeks and willing to undergo washed microbiota transplantation. 5.Willing to sign an informed consent form.
Exclusion criteria
Exclusion criteria: 1.History of antibiotic use for more than 3 consecutive days within the past 3 months. 2.History of active infection and gastrointestinal diseases such as inflammatory bowel disease and irritable bowel syndrome. 3.Definite diagnosis of severe gastrointestinal organic diseases such as gastrointestinal obstruction through digestive tract imaging or gastroscopy. 4.Severe complications of diabetes (including diabetic ketoacidosis, hyperosmolar hyperglycemic syndrome, lactic acidosis, hypoglycemia, etc.). 5.Thyroid diseases, severe cognitive dysfunction and mental illnesses, severe renal insufficiency. 6.Known history of alcohol or drug abuse. 7.Pregnancy or lactation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Gastroparesis Symptom Index ;Gastrointestinal Symptom Rating Scale ; | — |
Secondary
| Measure | Time frame |
|---|---|
| Composite Autonomic Symptom Score ;Gastrointestinal motility ;Heart rate variability ; | — |
Countries
China
Contacts
Public ContactDafa Ding
The Second Affiliated Hospital of Nanjing Medical University
Outcome results
None listed