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Effect of DL-3-n-butylphthalide before mechanical thrombectomy on ischemic penumbra and functional outcome in patients with acute ischemic stroke

Effect of DL-3-n-butylphthalide before mechanical thrombectomy on ischemic penumbra and functional outcome in patients with acute ischemic stroke

Status
Active, not recruiting
Phases
Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2400087508
Enrollment
Unknown
Registered
2024-07-29
Start date
2024-07-31
Completion date
Unknown
Last updated
2024-08-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

stroke

Interventions

Treatment group: butylphthalein
control group:Normal saline

Sponsors

Second people’s Hospital of Chengdu
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: (1) Aged 18-80; (2) Acute ischemic stroke was confirmed by head CT, MRI or DWI; (3) Patients with acute ischemic stroke: including anterior circulation and posterior circulation acute cerebral infarction; (4) NIHSS score of 6-24; (5) Within 24 hours after the onset of the disease (if the onset time is unknown, it means within 24 hours after the last normal data); (6) Subjects give informed consent, participate voluntarily, and sign informed consent.

Exclusion criteria

Exclusion criteria: (1) NIHSS>25; (2) ASPECTS24 hours; (4) Complicated with serious internal diseases: patients with cardiac pacemaker implantation, severe debilitation of heart, lung, liver and kidney functions, malignant tumors, various hemorrhagic diseases, coagulation disorders, acute infectious diseases, febrile diseases, women's menstrual period or pregnancy, etc.; (5) Patients who are participating in other clinical studies; (6) Patients who are allergic to butylphthalein; (7) contraindicated magnetic resonance examination.

Design outcomes

Primary

MeasureTime frame
security;symptomatic intracranial hemorrhage;

Secondary

MeasureTime frame
90d-mRS;

Countries

China

Contacts

Public ContactLanYing He

The Second People’s Hospital of Chengdu

531324679@qq.com+86 151 0826 7609

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026