Gynecological diseases
Conditions
Interventions
pilot study - oliceridine group:oliceridine 1mg
pilot study - sufentanil group:sufentanil 5µg
formal trial - oliceridine group:oliceridine 1mg
formal trial - sufentanil group:sufentanil 5µg
Sponsors
The Second People‘s Hospital Of Shantou
Eligibility
Sex/Gender
Female
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18 to 65 years, 2. Body mass index 18.5-24.9 kg/m², 3. ASA grade I-II, 4. Patients and their relatives are fully informed about anesthesia and related risks, and have signed an informed consent form for anesthesia.
Exclusion criteria
Exclusion criteria: 1.Uterine or cervical anatomical abnormalities, intrauterine adhesions, complex surgical procedures with anticipated significant trauma and prolonged duration; 2.Concurrent cardiovascular or respiratory diseases; 3.Severe cardiac, pulmonary, hepatic, or renal dysfunction; 4.Long-term history of smoking and alcohol abuse; 5.Allergy to propofol, opioids, or other anesthetic drugs; 6.History of alcohol or substance abuse; 7.Severe preoperative anemia or need for intraoperative blood transfusion; 8.Psychiatric disorders; 9.Moderate to severe sleep apnea.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| QoR-15 score at 24 hours after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Vital signs(HR, SBP, DBP, SPO2, RR);Adverse reactions(Hypotension, bradycardia, respiratory depression, and postoperative symptoms such as headache, nausea, vomiting, cough, shivering, and hypoxemia);Onset of sedation;Propofol dosage during surgery;Recovery time; | — |
Countries
China
Contacts
Public ContactZongxing Ke
The Second People‘s Hospital Of Shantou
Outcome results
None listed