Effect of deep vs moderate neuromuscular block on chronic postsurgical pain after lumbar spinal fusion: a randomized controlled trial

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2400087489

Enrollment

Unknown

Registered

2024-07-29

Start date

2024-08-01

Completion date

Unknown

Last updated

2024-08-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

lumbar spinal fusion, chronic postsurgical pain, paraspinal muscle injury

Interventions

Group M:Intraoperative maintenance of moderate muscle relaxation (TOF: 1-2)

Group D:Intraoperative maintenance of deep muscle relaxation (PTC: 1-2)

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Aged >= 18 years; 2. ASA<? 3. Patients undergoing open posterior lumbar fusion surgery for lumbar degenerative diseases

Exclusion criteria

Exclusion criteria: 1. Known allergy to rocuronium and sugammadex sodium; 2. Presence of central and peripheral nervous system, neuromuscular system diseases (poliomyelitis, peripheral neuropathy,etc.) and equipped with pacemakers; 3. Severe arrhythmia, heart failure, respiratory diseases, and severe liver and kidney dysfunction; 4. History of alcohol or drug abuse; 5. Family history of malignant hyperthermia 6. History of spinal surgery; 7. Communication or cognitive dysfunction

Design outcomes

Primary

Measure	Time frame
Incidence of chronic postsurgical pain 3 months after surgery;	—

Secondary

Measure	Time frame
Incidence of chronic postsurgical pain 6 months after surgery;numerical rating scale 2h, 12h, 24h, 48h,36h,3 months,6 months after operation;Intraoperative muscle relaxant usage;Intraoperative dosage of sufentanil , remifentanil;Incidence of using extra analgesic in PACU;Postoperative analgesic dosage;15-item quality of recovery scale score on the third day after surgery, 3 months and 6 months after surgery;Surgical evaluation;blood loss;Extubation time;The incidence of severe hypoxemia(SpO2<80%);Length of hospital admission;Readmission/admission rate for pain within 6 months;Oswestry disability index in 3 and 6 months after operation;Markers of muscle injury;Markers of inflammation;Cross-sectional area and fat infiltration of paraspinal muscle 6 months after operation;Operation duration;	—

Measure

Time frame

Incidence of chronic postsurgical pain 6 months after surgery;numerical rating scale 2h, 12h, 24h, 48h,36h,3 months,6 months after operation;Intraoperative muscle relaxant usage;Intraoperative dosage of sufentanil , remifentanil;Incidence of using extra analgesic in PACU;Postoperative analgesic dosage;15-item quality of recovery scale score on the third day after surgery, 3 months and 6 months after surgery;Surgical evaluation;blood loss;Extubation time;The incidence of severe hypoxemia(SpO2<80%);Length of hospital admission;Readmission/admission rate for pain within 6 months;Oswestry disability index in 3 and 6 months after operation;Markers of muscle injury;Markers of inflammation;Cross-sectional area and fat infiltration of paraspinal muscle 6 months after operation;Operation duration;

—

Countries

China

Contacts

Public ContactSu Liu

The Affiliated Hospital of Xuzhou Medical University

150040009@qq.com+86 181 1830 9692

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026