Early postoperative cognitive dysfunction
Conditions
Interventions
Group A: individualized beach posture routine rehydration group:Individualized beach posture and routine rehydration
Group B: individualized beach posture goal-directed hemodynamic therapy group:Individualized beach posture and goal-directed hemodynamic therapy
Group C: traditional beach posture routine rehydration group:Traditional beach posture and routine rehydration
Group D: target directed hemodynamic therapy group in traditional beach posture:Traditional beach posture and goal-directed hemodynamic therapy
Sponsors
Xi’an Honghui Hospital
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: 1) Patients who were treated in our hospital for the first time under general anesthesia combined with brachial plexus block for unilateral proximal humerus fracture surgery; 2) ASA class I-III; 3) Age = 65 years; 4) BMI index 18-30kg/m2; 5) The patient graduated from primary school or above, and could sign the informed consent.
Exclusion criteria
Exclusion criteria: 1) The patient refused to participate in this study; 2) Contraindications of brachial plexus block anesthesia; 3) Arrhythmia, congestive heart failure, severe heart valve disease; 4) Preoperative neurocognitive impairment, cerebrovascular events, and history of mental disorders; 5) Chronic obstructive pulmonary disease, chronic kidney disease; 6) Persistent infectious disease; 7) Pregnant patients and lactating women; 8) Patients with known allergy to any colloid; 9) Patients with severe vascular stenosis detected by transcranial Doppler ultrasound and carotid ultrasound.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mini-mental State Examination (MMSE) 1 day before operation;Mini-mental State Examination (MMSE) 1 day after operation;Verbal fluency test (VFT) 1 day before operation;Verbal fluency test (VFT) 1 day after operation;Clock drawing test (CDT) 1 day before operation: 4 points;Clock drawing test (CDT) 1 day after operation: 4 points;Symbol Digit Modalities Test (SDMT) 1 day before operation;Symbol Digit Modalities Test (SDMT) 1 day after operation;Auditory verbal learning test (avlt) 1 day before operation;Auditory verbal learning test (avlt) 1 day after operation;Trial making test (TMT) 1 day before operation;Trial making test (TMT) 1 day after operation;Boston Naming Test (BNT) score 1 day before operation;Boston Naming Test (BNT) score 1 day after operation; | — |
Secondary
| Measure | Time frame |
|---|---|
| Intraoperative urapidil dose;Duration of low cerebral oxygen saturation;Blood biochemical values 1 day before and 1 day after operation;hemodynamic parameter;rSO 2 level;Height difference between blood pressure zero and external auditory canal; | — |
Countries
China
Contacts
Public ContactWang Fang
Xi’an Honghui Hospital
Outcome results
None listed