Atrial fibrillation
Conditions
Interventions
CPAP group (The CPAP group underwent catheter ablation and CPAP treatment for AF combined with OSA):NA
non-CPAP group (The non-CPAP group underwent catheter ablation and conventional treatment for AF combined with OSA):NA
Sponsors
The Second Affiliated Hospital of Soochow University
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: 1. Clinical diagnosis of AF combined with moderate to severe OSA (OSA diagnostic criteria: apnea hypopnea index (AHI) greater than 15/hour, and at least 80% of all events are respiratory sleep obstructive events; AF includes persistent atrial fibrillation and paroxysmal atrial fibrillation) 2. Age = 18 years old 3. The patient voluntarily participates in the project and signs informed consent 4. All patients undergo overnight sleep pressure titration at the sleep center to determine the minimum pressure value for continuous positive airway pressure ventilation at home. All patients are required to undergo CPAP treatment at home at least 5 days a week, with each session lasting at least 4 hours
Exclusion criteria
Exclusion criteria: 1. Patients with neuromuscular disorders, pulmonary hypopnea, and severe lung diseases 2. Preoperative confirmation of thrombus in the left atrium 3. The patient has no desire for conversion 4. Secondary atrial fibrillation (hyperthyroidism, tumors, etc.) 5. Individuals with contraindications to anticoagulants 6. Left atrial diameter (LAD) exceeding 60mm (2D echocardiography long axis section data) 7. Pregnant women 8. History of myocardial infarction, percutaneous coronary intervention, and cardiac surgery in the past three months 9. Stroke or transient ischemic attack in the past six months 10. After artificial valve implantation surgery 11. Severe renal insufficiency (creatinine Cr>2.5mg/dl or>221umol/L, or glomerular filtration rate eGFR<30ml/min/1.73m2) 12. Acute diseases or active infections that occur before surgery, recorded as pain, fever, positive blood culture, and/or leukocytosis, or have been treated with antibiotics. 13. Expected survival period<1 year
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| AF recurrence after ablation;AF burden after ablation; | — |
Secondary
| Measure | Time frame |
|---|---|
| The recurrence of AF after combination with antiarrhythmic drugs;AF burden after combination with antiarrhythmic drugs;SF-36;Euro-QoL5D Survey Scoring; | — |
Countries
China
Contacts
Public ContactFeng Li
The Second Affiliated Hospital of Soochow University
Outcome results
None listed