Effect of subdose esketamine on postoperative anxiety and depression in patients with breast cancer

Effect of subdose esketamine on intraoperative hemodynamics and postoperative anxiety and depression in patients with breast cancer

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2400087464

Enrollment

Unknown

Registered

2024-07-29

Start date

2024-07-29

Completion date

Unknown

Last updated

2024-08-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

breast cancer

Interventions

experimental group:The drug was administered at 0.2mg/kg during induction and 0.1mg/kg during anesthetic maintenance until the end of surgery. Drug induction and maintenance with 50mg diluted with nor

control group:Administer the same dose of physiological saline during induction and maintenance

Eligibility

Sex/Gender

Female

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: ? Adult women aged 18-65 years with ASA grades I - III ? Preoperative biopsy confirmed the diagnosis of breast cancer and underwent surgical treatment ? Clear consciousness, no communication barriers

Exclusion criteria

Exclusion criteria: ? Patients who refuse to sign informed consent ? There are contraindications to esketamine use, such as refractory hypertension, severe cardiovascular disease and hyperthyroidism. ? Patients with serious diseases of important organs ? He has a history of mental illness

Design outcomes

Primary

Measure	Time frame
PHQ-9;SAS;	—

Secondary

Measure	Time frame
blood;heart;NRS;	—

Countries

China

Contacts

Public ContactMingqiang Zhao

Rehabilitation University Qingdao Central Hospital

zhmq10@163.com+86 186 6141 6075

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026