Aging
Conditions
Interventions
The experiment group :The subjects are made to take in oxygen by masks under 2.0 ATA in chamber. Treatments are given once a day for a total duration of 100 minutes each, 6 times a week.
The control group:The subjects are made to take in oxygen by masks under 1.04 ATA in chamber. Treatments are given once a day for a total duration of 100 minutes each, 6 times a week.
Sponsors
Depart of Plastic & Reconstructive Surgery, The Ninth People's Hospital of Shanghai Jiaotong University School of Medicine
Eligibility
Sex/Gender
All
Age
60 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age >= 60 years (No gender restrictions); 2. No serious organic or psychiatric disease; 3. Not having received hyperbaric oxygen therapy within half a year prior to baseline; 4. Willingness to maintain a consistent diet and lifestyle throughout the study period; 5. Informed consent to the purpose and content of the study.
Exclusion criteria
Exclusion criteria: 1. Patients with comorbid psychiatric disorders; 2. Patients unwilling to sign an informed consent form; 3. Unwillingness to co-operate and factors affecting compliance; 4. Uncontrolled hypertension (systolic blood pressure >= 140 mmHg, and/or diastolic blood pressure >= 90 mmHg); 5. History of hyperbaric oxygen therapy within six months prior to baseline; 6. Severe pulmonary dysfunction; 7. History of malignancy in the past year; 8. Pathological cognitive decline; 9. Severe chronic renal failure (GFR = 8%, and/or fasting blood glucose >= 11.1 mmol/L); 11. Receiving immunosuppressive therapy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Senescence-associated secretory phenotype; | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood routine examination;Blood biochemical examination;Oxidative stress levels in serum samples;Dermoscopic features ;Life quality score;Multi-omics sequencing and joint analysis;Carotid artery ultrasound;Body composition examination;Behavioral tests;Pulmonary function test; | — |
Countries
China
Contacts
Public ContactCaiyue Liu
Depart of Plastic & Reconstructive Surgery, The Ninth People's Hospital of Shanghai Jiaotong University School of Medicine
Outcome results
None listed