post-stroke aphasia
Conditions
Interventions
Experimental group:Executive function training+routine speech rehabilitation training
Observation group:No
Normal control group:No
Sponsors
Beijing Tiantan Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.The mother tongue is Mandarin Chinese, the second language level is limited, and is right-handed judged by the Edinburgh Handedness Inventory; 2.Age=18 years old, years of schooling=6 years (primary school education and above); 3.The first time of stroke, confirmed by CT/MRI as ischemic stroke, is located in the left cerebral hemisphere; 4. The lesion is single, and is in the acute stage of stroke, that is, within 2 weeks of onset; 5. The main symptom is language dysfunction and is evaluated as BA by the Western Aphasia test; 6. The degree of aphasia is mild (the severity of aphasia in the Boston Diagnostic Aphasia Test is graded at 3-4); 7. Able to complete cognitive psychology assessment; 8. No contraindications for MRI examination; 9. Informed consent has been signed.
Exclusion criteria
Exclusion criteria: 1.Pre-onset language dysfunction, including but not limited to aphasia, dysarthria, and speech apraxia; 2.There are types of speech disorders other than aphasia after the onset, including but not limited to dysarthria and speech apraxia; 3.Prior to onset, there was a history of cognitive impairment, including amyloid cerebrovascular disease, autosomal dominant cerebral artery disease accompanied by subcortical infarction and leukoencephalopathy, neurodegenerative disease and other diseases that may cause cognitive impairment; 4.Neuroimaging findings showed small cerebral vascular lesions such as white matter lesions, microbleeding, perivascular space enlargement, cerebral atrophy, lacunar infarction, etc. 5.Failure to complete the assessment: disturbance of consciousness, Glasgow coma score<15; the muscle strength of the right limb=grade 3 that cannot be matched to complete the evaluation; 6.Potentially dangerous past medical history: history of epilepsy; history of mental health problems; severe visual and hearing impairment; severe heart, lung, liver and kidney insufficiency; 7.Received any type of speech and cognitive therapy before enrollment; 8.There are contraindications for MRI examination (claustrophobia, inremovable metal stent, cochlear implant, etc.); 9.Informed consent has not been signed.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| West Aphasia Battery,WAB;Chinese Aphasia Language Battery(Standard Edition),CALB;Boston Diagnostic Aphasia Examination,BDAE;Boston Naming Test,BNT;Word Fluency Test,WFT;Resting state functional nuclear magnetic related indicators;Edinburgh Handedness Inventory;Chinese Aphasia Fluency Characteristics Scale;Stroop Color Word Test;Digital span scale;Wsiconsin card sorting test,WCST; | — |
Secondary
| Measure | Time frame |
|---|---|
| Loewenstein Occupational Therapy Cognitive Assessment,LOTCA;Activities of Daily Living Scale,ADL;Stroke Aphasic Depression Questionnaire Hospital Version,SADQ-H;modified Rankin scale,MRS; | — |
Countries
China
Contacts
Public ContactYumei Zhang
Beijing Tiantan Hospital, Capital Medical University
Outcome results
None listed