Effect of different doses of esketamine on vagal reflex during cord polyp extraction

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2400087440

Enrollment

Unknown

Registered

2024-07-26

Start date

2024-08-01

Completion date

Unknown

Last updated

2024-07-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

cord polyp

Interventions

group A:normal saline

group B:esketamine 0.25mg/kg

group C:esketamine 0.5mg/kg

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria included patients aged 18 to 65 years with American Society of anesthesologists (ASA)classifications I and II undergoing elective supportive laryngoscopic vocal cord mass resection.

Exclusion criteria

Exclusion criteria: Exclusion criteria include a history of esketamine or ketamine allergy, a history of mental disorders, a serious risk of elevated blood pressure or intracranial pressure, untreated or poorly controlled hypertension, glaucoma, hyperthyroidism, ischemic heart disease or arrhythmia, severe liver and kidney dysfunction, pregnancy or lactation.

Design outcomes

Primary

Measure	Time frame
heart rate;mean arterial pressure;	—

Secondary

Measure	Time frame
Postoperative Pain;Adverse reactions;	—

Countries

China

Contacts

Public ContactXin Wang

The Second Xiangya Hospital of Central South University

42567915@qq.com+86 137 8722 4623

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026